Regulation of prostaglandin F2 and E receptor mRNA by prostaglandin F2 in ovine corpora lutea

Prostaglandin F2-alpha receptor regulation in human uterine myocytes.

Investigations of the modulation of prostaglandin F(2alpha) receptor (FP) expression in primary cultures of human uterine myocytes showed that FP mRNA expression was reduced by progesterone, unaltered by cAMP (8-bromo cAMP or forskolin), but increased by the PKA antagonist H89. Interleukin (IL)-1beta, tumour necrosis factor-alpha and oxytocin increased FP mRNA expression and IL-6 and prostaglan...

Temporal relationships between stress protein induction, progesterone withdrawal, and apoptosis in corpora lutea of ewes treated with prostaglandin F2 alpha.

Immunofluorescent staining was used to detect in situ alterations in inducible heat shock (stress) protein (HSP)-70 production and DNA fragmentation (indicative of apoptotic cell death) in luteal tissues obtained from sheep after in vivo administration of a luteolytic dose of PGF2 alpha. Accumulation of HSP-70 was localized to PG-sensitive (i.e., large) luteal cells. Cytoplasmic HSP-70 increase...

CREB Mediates Prostaglandin F2 -Induced MUC5AC Overexpression

Evaluation of prostaglandin F2 alpha and hypertonic saline as abortifacients.

The intraamnio~ic instillation of various abortifacients is becoming increasingly popular as a ~:limple, ambulatory, nonsurg"cal me hod of termination of midtrimester pregnancies. · It is in this context that hypertonic solutions, specially 20% saline, and the more recently d'scovered prostagland:ns of the E and F series have featured prominently in large abortion serie:.. Though extensively us...

Prostaglandin E2 and prostaglandin F2 alpha biosynthesis in human gastric mucosa: effect of chronic alcohol misuse.

BACKGROUND AND AIMS The results of experimental studies support the hypothesis that decreased prostaglandin production might play a part in the gastric mucosal injury induced by alcohol. In this study, it was investigated whether alcohol misuse impairs the synthesis of prostaglandin E2 (PGE2) and prostaglandin F2 alpha (PGF2 alpha) in gastric mucosa. PATIENTS Fifty six alcoholic patients and ...